Team NO

Nitric oxide (NO) is a powerful signaling molecule with far reaching effects. Inspired by Cu and Zn environments in biology, we employ synthetic models that outline pathways to interconvert molecules in NO signaling such as nitrate, nitrite, and S-nitrosothiols (RSNO).

Copper(II) thiolates [Cu(II)]-SR reversibly capture NO to form [Cu(I)](RSNO)
S-nitrosothiol adducts, revealing new pathways for NO siganling at copper as well as to interconvert NO and RSNO molecular signals.

Nitrite bound to copper(II) undergoes facile converstion to R2N-NO, RO-NO, and RS-NO species to faciliate nitrite, RSNO, and NO interconversion.

Copper(II) - but not copper(I) - activates nitrite towards O-atom transfer (OAT) to strong nucleophiles.

Lewis acid (LA) binding to S-nitrosothiols facilitate reduction, changing the signaling output from NO to N2O.

A rare, side-on nitrosyl complex enables N-N bond formation at a mononuclear site.

Current Team Members

Pokhraj Ghosh, Ph.D.
E-mail: ghoshpok@msu.edu
NO coupling via Cu-nitrosyls

Danushka Ekanayake, Ph.D.
E-mail: ekanaya7@msu.edu
NO coupling at Fe/Cu

Shreya Ray Chaudhuri
E-mail: raychau3@msu.edu
Electron transfer in NO assembly at copper

Carolynn Calin
E-mail: calincar@msu.edu
Nitrite reduction via C-H bonds

Chemistry for a Healthy Planet

The Warren Lab

Team NO

Copper(II) thiolates [Cu(II)]-SR reversibly capture NO to form [Cu(I)](RSNO)
S-nitrosothiol adducts, revealing new pathways for NO siganling at copper as well as to interconvert NO and RSNO molecular signals.

Nitrite bound to copper(II) undergoes facile converstion to R2N-NO, RO-NO, and RS-NO species to faciliate nitrite, RSNO, and NO interconversion.

Copper(II) - but not copper(I) - activates nitrite towards O-atom transfer (OAT) to strong nucleophiles.

Lewis acid (LA) binding to S-nitrosothiols facilitate reduction, changing the signaling output from NO to N2O.

A rare, side-on nitrosyl complex enables N-N bond formation at a mononuclear site.

Current Team Members

Pokhraj Ghosh, Ph.D.
E-mail: ghoshpok@msu.edu
NO coupling via Cu-nitrosyls

Danushka Ekanayake, Ph.D.
E-mail: ekanaya7@msu.edu
NO coupling at Fe/Cu

Shreya Ray Chaudhuri
E-mail: raychau3@msu.edu
Electron transfer in NO assembly at copper

Carolynn Calin
E-mail: calincar@msu.edu
Nitrite reduction via C-H bonds

Shubham Jha
E-mail: jhashub3@msu.edu
Low-coordinate Cu-nitrosyls

Team NO

Copper(II) thiolates [Cu(II)]-SR reversibly capture NO to form [Cu(I)](RSNO) S-nitrosothiol adducts, revealing new pathways for NO siganling at copper as well as to interconvert NO and RSNO molecular signals.

Nitrite bound to copper(II) undergoes facile converstion to R2N-NO, RO-NO, and RS-NO species to faciliate nitrite, RSNO, and NO interconversion.

Copper(II) - but not copper(I) - activates nitrite towards O-atom transfer (OAT) to strong nucleophiles.

Lewis acid (LA) binding to S-nitrosothiols facilitate reduction, changing the signaling output from NO to N2O.

A rare, side-on nitrosyl complex enables N-N bond formation at a mononuclear site.

Current Team Members

Pokhraj Ghosh, Ph.D. E-mail: ghoshpok@msu.edu NO coupling via Cu-nitrosyls

Danushka Ekanayake, Ph.D. E-mail: ekanaya7@msu.edu NO coupling at Fe/Cu

Shreya Ray Chaudhuri E-mail: raychau3@msu.edu Electron transfer in NO assembly at copper

Carolynn Calin E-mail: calincar@msu.edu Nitrite reduction via C-H bonds

Shubham Jha E-mail: jhashub3@msu.edu Low-coordinate Cu-nitrosyls

Copper(II) thiolates [Cu(II)]-SR reversibly capture NO to form [Cu(I)](RSNO)
S-nitrosothiol adducts, revealing new pathways for NO siganling at copper as well as to interconvert NO and RSNO molecular signals.

Pokhraj Ghosh, Ph.D.
E-mail: ghoshpok@msu.edu
NO coupling via Cu-nitrosyls

Danushka Ekanayake, Ph.D.
E-mail: ekanaya7@msu.edu
NO coupling at Fe/Cu

Shreya Ray Chaudhuri
E-mail: raychau3@msu.edu
Electron transfer in NO assembly at copper

Carolynn Calin
E-mail: calincar@msu.edu
Nitrite reduction via C-H bonds

Shubham Jha
E-mail: jhashub3@msu.edu
Low-coordinate Cu-nitrosyls