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Team C-H

Through mechanistic understanding of reactive copper intermediates, we develop new reactions to directly convert sp3 C-H to C-C, C-N, C-O, and C-S bonds.  These methods offer unique synthetic opportunities for the late stage functionalization of organic molecules.

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The isolation of a copper(II) alkynyl complex reveals the active intermediate in the 150 year old Glaser coupling of alkynes and suggests new roles in C-H functionalization to generate challenging quaternary carbon centers.

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A bulky catalyst enables C-H functionalization of strong, accessible C-H bonds in the presence of weaker, yet hindered, C-H bonds.

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Current Team Members

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Isuri Jayasooriya 

iuj2@georgetown.edu

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copper-catalyzed C-N and C-S bond formation

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Bryan Figula

bcf37@georgetown.edu

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copper-catalyzed C-C bond formation

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Ting-An Chen 

tc850@georgetown.edu

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copper-catalyzed C-C bond formation

YuJai Lin

yl1241@georgetown.edu

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DFT studies of C-C bond formation at copper

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