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Team C-H

Through mechanistic understanding of reactive copper intermediates, we develop new reactions to directly convert sp3 C-H to C-C, C-N, C-O, and C-S bonds.  These methods offer unique synthetic opportunities for the late stage functionalization of organic molecules.

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The isolation of a copper(II) alkynyl complex reveals the active intermediate in the 150 year old Glaser coupling of alkynes and suggests new roles in C-H functionalization to generate challenging quaternary carbon centers.

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A bulky catalyst enables C-H functionalization of strong, accessible C-H bonds in the presence of weaker, yet hindered, C-H bonds.

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Current Team Members

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Ting-An Chen
E-mail: chenti52@msu.edu
C-H alkenylation and prenylation
 

Milad Pedarpourvajargahy
E-mail: pedarpou@msu.edu
C-H functionalizaiton with C-H acids

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Sonam Shivtarkar
E-mail: shivtark@msu.edu
C-H amination with ammonia
 

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Anuki Wethalawe
E-mail: wethalaw@msu.edu
Site selectivity in C-H amination

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Nathan Slater
E-mail: slaterna@msu.edu
C-H methylation

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Salma Begum
E-mail: begumsal@msu.edu
Strategies for chiral catalyst design
 

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